Past Grant Recipients

JULIO AGUIRRE-GHISO, PhD

Icahn School of Medicine

Targeting Intrinsic And Immune Mechanisms In Persistent Dormant Cancer Cells In Stage IV Breast Cancer

Abstract Report

CHARLES CLEVENGER, MD, PhD

Virginia Commonwealth University

Inhibition of breast cancer metastatic outgrowth with non-immunosuppressive cyclosporine

Abstract Report

VERA DONNENBERG, PhD

University of Pittsburgh School of Medicine UPMC Hillman Cancer Center

Assays to determine optimal dosing and therapeutic effects of localized immunotherapy for established metastatic breast cancer t

Abstract Report

GLORIA ECHEVERRIA, PhD

MD Anderson Cancer Center

Elucidation and functionalization of transcriptomic heterogeneity of established multi-organ metastases in patient-derived xenog

Abstract Report

DORRAYA EL-ASHRY, PhD

University of Minnesota School of Medicine

Eliminate breast cancer metastasis by targeting the tumor microenvironment

Abstract Report

XU FENG, PhD

University of Alabama at Birmingham

Development of Targeted Drugs for Treating Breast Cancer Bone Metastasis

Abstract Report

JANET FUNK, MD

University of Arizona Cancer Center

Improving Survival in Stage IV Breast Cancer by Targeting Dormant Breast Cancer Cells in Bone

Abstract Report

ANA GARRIDO-CASTRO, MD

Dana-Farber Cancer Institute

Identifying predictive biomarkers of response to PD-1 inhibition in metastatic triple-negative breast cancer

Abstract Report

MARK HEADLEY, PhD

Fred Hutchinson Cancer Research Center

Monocyte Contribution To Lung Metastasis Of Breast Cancer

Abstract Report

FRANSISCA LEONARD, PhD

Houston Methodist Hospital Research Institute

CRISPR-nanoparticle for macrophage reprogramming: New therapeutic strategy for breast cancer liver metastasis

Abstract Report

SOPHIA LUNT, PhD

Michigan State University

Targeting Sialic Acid Metabolism to Stop Metastatic Breast Cancer

Abstract Report

ELIZABETH MCDONALD, MD, PhD

University of Pennsylvania

In vivo visualization and quantification of pharmacodynamics response to PARPi therapy

Abstract Report

ERIK NELSON, PhD

University of Illinois

Targeting an immune-suppressive cholesterol metabolite in the treatment metastatic breast cancer

Abstract Report

JOSH NEMAN, PhD

University of Southern California

Chemotherapy and tau interplay permeabilize BBB and facilitate brain metastasis

Abstract Report

AXEL SCHÖNTHAL, PhD

University of Southern California

Controlled Opening of the Blood-Brain Barrier to Achieve Therapeutic Access of Trastuzumab in HER2-Positive Brain Metastases

Abstract Report

BRAD ST CROIX, PhD

National Cancer Institute

Improving Immunotherapies for Advanced Metastatic Breast Cancer

Abstract Report

RACHEL STEWART, PhD

University of Kentucky

Characterizing Metastatic Breast Cancer Heterogeneity through Post-Mortem Tissue Collection

Abstract Report

WEI TAO, PhD

Harvard Medical School/Brigham and Women’s Hospital

Multi-staged delivery system overcoming the physiological barriers for metastatic breast cancer (MBC) therapy

Abstract Report

MICHAEL WENDT, PhD

Purdue University

Enhancing anti-metastatic immunity through targeted inhibition of SHP2 phosphatase

Abstract Report

THOMAS WESTBROOK, PhD

Baylor College of Medicine

Microenvironment response disparities of metastatic TNBC to multi-tyrosine kinase inhibition

Abstract Report

DIHUA YU, MD, PhD

MD Anderson Cancer Center

Combating Breast Cancer Brain Metastasis by Blocking CDK5 Driver Kinase Function

Abstract Report

FIONA YULL, PhD

Vanderbilt School of Medicine

Macrophage-based immunotherapy for eradication of pre-existing breast cancer metastases

Abstract Report

DIANA CITTELLY, PhD

University of Colorado Anschutz Medical Campus

Targeting BDNF/TrkB in Brain Metastasis from Young Women with TNBC

Abstract Report

MICHAEL FLISTER, PhD

Medical College of Wisconsin

Personalized Therapy for Curing Metastatic Breast Cancer

Abstract Report

ANDREI GOGA, MD, PhD

University of California, San Francisco

Targeting the MYC Pathway in Metastatic Breast Cancer

Abstract Report

MELANIE HAYDEN GEPHART, MD, MAS

Leland Stanford Junior University

Halting the Progression of Breast Cancer Leptomeningeal Brain Metastases

Abstract Report

CHERYL JORCYK, PhD

Boise State University

High Impact Therapeutic for the Elimination of Breast Cancer Metastasis to Bone

Abstract Report

JAMES MCINTYRE, MA, PhD AND BARBARA FINGLETON, PhD

Vanderbilt University

A Novel Self-Reporting Paclitaxel Prodrug without Systemic Neurotoxicity: Preclinical Assessment for Targeted Treatment of Metas

Abstract Report

VIVEK MITTAL, PhD

Weill Medical College of Cornell University

Targeting Epigenetic Regulator PRC2 as a Therapy for Established Metastasis

Abstract Report

PARTHA ROY, PhD

University of Pittsburgh

Pharmacological Inhibition of Myocardin-Family Proteins as a Novel Strategy to Combat Metastatic Breast Cancer

Abstract Report

REBECCA WATTERS, PhD

University of Pittsburgh

Discovery of Clinically Actionable Genes in Breast Cancer Bone Metastases

Abstract Report

PAULA BOS, PhD

Virginia Commonwealth University

Regulatory T Cell Promotion of Brain Metastatic Processes

Abstract Report

IAN CORBIN, PhD

University of Texas Southwestern Medical Center

Lipoprotein Omega-3 Fatty Acid Nanoparticles: A Novel Treatment for Breast Cancer Liver Metastases

Abstract Report

KATHLEEN GALLO, PhD

Michigan State University

Deciphering and Targeting Signaling Nodes that Drive Metastatic Breast Cancer

Abstract Report

TODD GIORGIO, PhD

Vanderbilt University

Quantitative Characterization of Anti-Tumor Immune Response in Metastatic Breast Cancer Induced by Focused Ultrasound

Abstract Report

PATRICIA SHEEAN, PhD, RDN

Loyola University Chicago

Is lean soft tissue (i.e., skeletal muscle) a potentially modifiable biomarker predictive of prognosis, treatment tolerance and

Abstract Report

SENDURAI A. MANI, PhD

University of Texas MD Anderson Cancer Center

Targeting Cancer Stem Cells to Treat Metastasis

Abstract Report

Summary Report

KATHERINE LOREE COOK, PhD

Wake Forest University

Dietary Considerations Effecting Lung Metastatic Therapeutic Responsiveness and Co-Morbidities

Abstract Report

Summary Report

JOSHUA DONALDSON, MD, PhD

Johns Hopkins University

Resistance Mechanisms to Palbociclib in Hormone Positive Metastatic Breast Cancer

Abstract Report

Summary Report

GINA SIZEMORE, PhD

Ohio State University

Targeting Novel Tumor-Stroma Interactions in Breast Cancer Brain Metastases

Abstract Report

Summary Report

DAVID SOTO-PANTOJA, PhD

Wake Forest School of Medicine Comprehensive Cancer Center

Anti-CD47 Immunotherapy as a Treatment for Metastatic Breast Cancer

Abstract Report

Summary Report

KATHRYN SCHWERTFEGER, PhD

University of Minnesota

Development of Immune-based Strategies to Enhance Therapeutic Targeting of Metastatic Breast Cancer

Abstract Report

Summary Report

BRAD ST. CROIX, PhD

National Cancer Institute Center for Cancer Research

Improving Therapy for Metastatic Breast Cancer through Targeting of Tumor Stroma

Abstract Report

Summary Report

J. CHUCK HARRELL, PhD

Virginia Commonwealth University

Genomic Dissection of Patient-Derived Xenograft Breast Cancer Liver Metastasis Models

Abstract Report

Summary Report

YIBIN KANG, PhD

Princeton University

Development of a Humanized Mouse Model of Breast Cancer Liver Metastasis

Abstract Report

Summary Report

YIBIN KANG, PhD

Princeton University

Sensitizing Bone Metastasis to Chemotherapy and Radiotherapy by Targeting Jagged1-Mediated Tumor-Stromal Interactions

Abstract Report

Summary Report

BONNIE KING, PhD and CHRISTOPHER CONTAG, PhD

Stanford University

Modeling Therapeutic Strategies for Breast Cancer Metastasis to Bone

Abstract Report

Summary Report

JITESH PRATAP, PhD

Department of Anatomy & Cell Biology

Novel Regulatory Mechanisms of Cell Survival During Bone Metastasis of Breast Cancer

Abstract Report

Summary Report

TIFFANY SEAGROVES, PhD

University of Tennesee Health Science Center

Targeting Creatine Kinases to Inhibit Metastatic Breast Cancer

Abstract Report

Summary Report

GEORGE SGOUROS, PhD

Johns Hopkins University, School of Medicine

A Pre-Clinical Model of anti-HER2/neu-Antibody Reactive Breast Cancer Metastases

Abstract Report

Summary Report

HAIFA SHEN, PhD, MD

Houston Methodist Research Institute

Harnessing Vascular and Cellular Depots of Nanotherapeutics for the Treatment of Metastatic Breast Cancer

Abstract Report

Summary Report

KAY-UWE WAGNER, Phd

University of Nebraska Medical Center

Identification of Candidate Target Genes for Metastasis and Cancer Cell Dormancy in a Novel Triple-Negative Breast Cancer Model

Abstract Report

Summary Report

MICHAEL WENDT, PhD

Purdue University Center for Cancer Research

Targeting Growth-Factor Receptor Discordant Metastatic Breast Cancer

Abstract Report

Summary Report

ELIZABETH YEH, PhD

Medical University of South Carolina

Application of a Connexin 43 (Cx43) Targeted Agent for the Treatment of Metastatic Breast Cancer

Abstract Report

Summary Report

SWARNALI ACHARYYA, PhD

Institute for Cancer Genetics, Columbia University

Reactivating anti-tumor granulocytic cells to provoke immune attack against breast cancer metastasis

Abstract Report

Summary Report

Eran Andrechek, Ph.D.

Michigan State University

Identification of driver mutations that regulate metastasis

Abstract Report

BALAMURUGAN KUPPUSAMY, PhD

NCI/NIH

Inflammatory Breast Cancer: Role of the CEBPD-FBXW7 Signaling Pathway

Abstract Report

Summary Report

WILLIAM SCHIEMANN, PhD

Case Western Reserve University

Implementing a Forward Genetic Screen to Identify Novel Proto-Oncogenes Operant in Overcoming Metastatic Dormancy

Abstract Report

Summary Report

SOFIA MERAJVER, MD

University of Michigan Comprehensive Cancer Center

Engineering cancer metastases platforms for precise medicine

Abstract Report

DOUGLAS HURST, Ph.D.

University of Alabama at Birmingham, Alabama

Improving oncolytic herpes simplex virus for metastatic breast cancer

Abstract Report

Summary Report

DAVID LUM, Ph.D.

Oklahoma Medical Research Foundation

Validation of patient-derived breast tumor grafts as predictors of tumor evolution and drug resistance

Abstract Report

DIHUA YU, M.D., Ph.D.

The University of Texas MD Anderson Cancer Center

Identification and Targeting of Kinases Involved in Breast Cancer Brain Metastasis

Abstract Report

Summary Report

CANDECE L. GLADSON, M.D.

Cleveland Clinic

FIP200 promotes survival through autophagy of metastatic breast cancer in the brain

Abstract Report

HEIDE L. FORD, PH.D.

University of Colorado School of Medicine

Understanding the Role of miR106b-25 in Breast Cancer Associated Metastasis: A potential new metastasis therapy

Abstract Report

RAHUL JANDIAL, MD, PHD

City of Hope Comprehensive Cancer Treatment Center in California

Disrupting metabolic adaptations in breast-to-brain metastases

Summary Report

Alana Welm, PhD

Test the value of tumorgrafts in predicting response to therapy.

Abstract Report

Summary Report

ANDREA M. MASTRO, PhD

The Pennsylvania State University

Dormancy or growth? A three dimensional in vitro system to study breast cancer metastases in bone

Summary Report

Danny Welch, PhD

University of Kansas Cancer Center

KISS1 prevents seeded cancer cells from growing into full blown metastases

Summary Report

View Active Grant Recipients