Grants Awarded

The METAvivor Research Program was established in 2009 with the specific goal of funding stage IV metastatic breast cancer research to one day, end death from metastatic breast cancer (MBC). The following list includes current and past grant recipients along with their progress reports.

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ACTIVE GRANT RECIPIENTS



2020

Adrian Lee, PhD

University of Pittsburgh, UPMC Hillman Cancer Center

Targeting RET for the treatment of breast cancer brain metastasis

Abstract Report

Blake “Eason” Hildreth, DVM, MS, PhD

University of Alabama, Birmingham

Targeting the CSF1R/PU.1 axis and PU.1/BET super-enhancer regulome in breast cancer bone metastasis

Abstract Report

Julie Di Martino, PhD

Icahn School of Medicine at Mount Sinai

Targeting dormant breast cancer cells with ACE inhibitors

Abstract Report

Nathan Reticker-Flynn, PhD

Stanford University

Targeting lymph node-induced immune tolerance to treat metastatic breast cancer

Abstract Report

Lou Song, PhD

University of Virginia

Oncogenic TRIM37 is a new driver of metastasis in triple negative breast cancer patients

Abstract Report

Tae-Hyung Kim, PhD

University of New Mexico

Harnessing cell mechanotype to regulate the immune evasion of highly metastatic breast cancer cells

Abstract Report

Reva Basho, MD

Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute

Presented by Metavivor Facebook Fundraisers

Tucatinib in Combination with Pembrolizumab and Trastuzumab for Patients with HER2+ Breast Cancer Brain Metastases

Abstract Report

Isaac Chan, MD, PhD

UT Southwestern Medical Center

Presented by #Lindasbug: A VW Beetle Fundraiser in Memory of Linda Kreizenbeck

Using natural killer cells to eliminate breast cancer metastases

Abstract Report

Jessica Christenson, PhD

University of Colorado Anschutz Medical Campus

Presented by Metavivor Facebook Fundraisers

Repurposing Lung Microenvironment Targeted Therapies for the Treatment of Established Breast Cancer Lung Metastases

Abstract Report

Erin Howe, PhD

University of Notre Dame-Harper Cancer Research Institute

Presented in memory of Erin Remme by Minneapolis Metsquerade

Targeting endosomal trafficking to enhance immune recognition of breast cancer brain metastases

Abstract Report

Natasha Hunter, MD

University of Washington

Presented by Metavivor Facebook Fundraisers

Tissue and liquid biopsy for breast cancer patients with bone-only metastases

Abstract Report

Dennis Jones, PhD

Boston University

Presented by Metavivor Facebook Fundraisers

Targeting breast cancer plasticity and immunosuppression in metastatic lymph nodes

Abstract Report

Srinivas Malladi, PhD

UT Southwestern Medical Center

Presented in Honor of Abbey Rapoport

Targeting vulnerabilities of immune-evasive HER2+ Breast Adenocarcinoma Metastasis Initiating Cells

Abstract Report

Shreyas Rao, PhD

The University of Alabama

Presented by Metavivor Facebook Fundraisers

Engineered biomimetic hydrogels to probe metastatic tumor cell cluster–brain microenvironment interactions facilitating tumor progression

Abstract Report

Thu Truong, PhD

University of Minnesota, Masonic Cancer Center

Presented by MetaRaise DENJPA in Memory of Our Friend Patty Ann Baldwin

Progesterone receptor reprograms metabolic pathways to drive therapy resistant populations in metastatic breast cancer

Abstract Report

Yun Zhao, PhD

University of Notre Dame

Presented by Metavivor Facebook Fundraisers

Targeting the pitfall of chemo-immunotherapy: Immunosuppressive myeloid cells induced by apoptosis

Abstract Report

Guizhi Zhu, PhD

Virginia Commonwealth University

Presented by Southwest Florida Metsquerade in Memory of Amanda DeFiebre

Multi-epitope/di-adjuvant co-delivering albumin-binding vaccines (Medico-AlbiVax) for the combination immunotherapy of metastati

Abstract Report

Stacy Blain, PhD

The Research Foundation of the State of New York, SUNY Downstate Medical Center

Presented by #LightUpMBC and Moore Fight Moore Strong in memory of Jessica Moore

p27Kip1: A game changing target in metastatic breast cancer

Abstract Report

Fumito Ito, MD, PhD

Roswell Park Comprehensive Cancer Center Health Research Inc

Presented by Southwest Florida Metsquerade in Memory of Karin Petrocelli

In situ radio-immunotherapy to maximize the engagement of cross-presenting dendritic cells to treat metastatic breast cancer

Abstract Report

Bethany Kerr, PhD

Wake Forest School of Medicine

Presented in Honor of Beth Fairchild and Her Service to Metavivor Research and Support

Profiling combinatorial treatment response in early and late bone metastatic breast cancer

Abstract Report

Traci Lyons, PhD

University of Colorado Anschutz Medical Campus

Presented by Northwest Arkansas Metsquerade In Memory of Erin Leland

Targeting therapeutic vulnerabilities of endocrine therapy resistant ER+ metastatic breast cancer

Abstract Report

Steffi Oesterreich, PhD

University of Pittsburgh

Presented by Facebook Fundraisers

Targeting mesothelial – tumor cell interaction to treat invasive lobular cancer metastases

Abstract Report

Selvarangan Ponnazhagan, PhD

The University of Alabama at Birmingham

Presented by Metavivor Facebook Fundraisers

Co-targeting immunosuppression and skeletal pathology for metastatic breast cancer therapy

Abstract Report

Pranela Rameshwar, PhD

Rutgers New Jersey Medical School

Presented in honor of Tami Bowling and METAvivors of NJ

Preventing epigenetic-mediated DNA repair induced by bone marrow niche cells to eliminate drug resistance

Abstract Report

Brad St Croix, PhD

National Cancer Institute

Presented by Monica Hill’s Be Bold and Behold, In Loving Memory of Monica Hill and Jasmine Charles

Improving the therapeutic index of ADCs targeting metastatic breast cancer

Abstract Report

Alana Welm, PhD

University of Utah

Presented by 2020 New York Fashion Week in Memory of Halli Lannan

FORESEE: Functional precision oncology for metastatic breast cancer: a feasibility trial

Abstract Report

Danny Welch, PhD

University of Kansas Medical Center Research Institute, Inc.

Presented by #Cancerland in Memory of Champagne Joy

BMRS1 MSD: A potential new inhibitor of breast cancer metastasis

Abstract Report

Stuart Martin, PhD

University of Maryland School of Medicine

Presented by the We "Neeta" Cure Fundraiser in Memory of Neta Meier

Targeting Tau-induced microtubule stabilization to reduce outgrowth of metastatic tumors

Abstract Report

2019

Nancy Lin, MD

Dana-Farber Cancer Institute

Overcoming Treatment Resistance in Breast Cancer Brain Metastases

Abstract Report

Bolin Liu, PhD

Department of Genetics Stanley S. Scott Cancer Center School of Medicine Louisiana State University Health Sciences Center

Presented in Memory of Cecilia “CeCe” Curry, METAvivor Board Member

IGF-2 in Herceptin refractory HER2-positive breast cancer

Abstract Report

Paul Lockman, PhD

West Virginia University

Timing of radiotherapy and chemotherapy to improve drug effect in brain metastases of breast cancer

Abstract Report

Deepali Sachdev, BSc, MSc, PhD

Regents University

Presented by 2019 NYFW + #Cancerland in memory of Champagne Joy

Development of natural killer cell based tri-specific killer engagers (TriKEs) as novel immunotherapy for metastatic breast canc

Abstract Report

Robert Weinberg, PhD

Whitehead Institute for Biomedical Research

Mechanisms of Acquired Adaptation of Disseminated Breast Cancer Cells

Abstract Report

Fei Xing, PhD

Wake Forest University

Treating breast cancer brain metastasis with immune checkpoint inhibitor and c-Met targeting agent

Abstract Report

Massimo Cristofanilli, MD

Northwestern University

Presented In Memory of Karen Presswood, Co-Founder of METAvivor

Unravelling New Cytokine-Mediated Mechanisms to Enhance Response to CDK4/6 inhibition in ER+/HER2-Metastatic Breast Cancer

Abstract Report

Andrew Ewald, PhD

Johns Hopkins University, School of Medicine

Presented In Memory of Avis Halberstadt, Co-Founder of Metavivor

Targeting the survival pathways required by established breast cancer metastases

Abstract Report

Carol Lange, PhD

University of Minnesota

Presented In Memory of Rhonda Rhodes, Co-Founder of Metavivor

Targeting Activated Progesterone Receptors in Metastatic Breast Cancer

Abstract Report

Prasanna Alluri, MD, PhD

UT Southwestern Medical Center at Dallas

Presented in honor of Erin Remme by Minneapolis Metsquerade

Identifying Therapeutic Vulnerabilities in RB1-negative, ER-positive Breast Cancers

Abstract Report

Lucia Borriello, PhD

Albert Einstein College of Medicine

Presented by 2019 New York Fashion Week

Targeting the Mechanism of Re-Dissemination and Metastasis in Stage IV Breast Cancer

Abstract Report

Joshua Drago, MD

Memorial Sloan Kettering Cancer

Presented by METAvivors of New Jersey

The intestinal microbiome and response to chemoimmunotherapy in patients with metastatic triple negative breast cancer (MTNBC)

Abstract Report

Mick Edmonds, PhD, MS

UAB School of Medicine

Presented In Memory of Kristin Todd

A novel strategy targeting SRC tyrosine kinase for breast cancer metastasis

Abstract Report

Colt Egelston, PhD

City of Hope

Presented In Memory of Angie Powell by Northwest Arkansas Metsquerade

Bispecific monoclonal antibodies for treatment of advanced breast cancer

Abstract Report

Jeremy Force, DO, MA

Duke University

Presented In Memory of Kristie Godwin Rolan by Triangle Metsquerade

Discovery and validation of putative oncogenic ROS1 alterations in breast cancer

Abstract Report

Jamie Fornetti, BA, PhD

Huntsman Cancer Institute, University of Utah

Presented by Abbey Rapoport

Novel RON Inhibitors for the Treatment of Metastatic Breast Cancer

Abstract Report

Antonio Giordano, MD, PhD

Medical University of South Carolina

Presented In Honor of Michael Kovarik by 2019 New York Fashion Week

Phase 1 clinical trial of Polo-like kinase 1 inhibition with nab-paclitaxel in TP53 mutated metastatic triple negative breast ca

Abstract Report

Sheheryar Kabraji, BMBCh

Dana-Farber Cancer Institute

Presented by 2019 METAbash

Targeting drug-resistant quiescent cancer cells in breast cancer brain metastases

Abstract Report

Jungwoo Lee, PhD

University of Massachusetts Amherst

Tissue-engineered bone to determine the impact of chemotherapy-induced premature aging in breast tumor metastasis

Abstract Report

Michael Lukey, PhD

Cornell University

Presented by Minneapolis Metsquerade in honor of Erin Remme

Targeting the unique metabolic profile of brain metastases in breast cancer

Abstract Report

Ashley Makela, PhD

The Institute for Quantitative Health Science and Engineering, Michigan State University

Presented In Memory of Connie Cadwell by Miles4Metavivor

Understanding extracellular vesicle trafficking in established breast cancer metastases: In vivo tri-modal imaging provides long

Abstract Report

Madeline Oudin, BSc, MSc, PhD

Tufts University

Presented by METAribbon Challengers

Investigating how obesity-driven changes in the tumor microenvironment promote metastatic outgrowth and chemoresistance in metas

Abstract Report

Lijuan Sun, PhD

Cold Spring Harbor Laboratory

Presented In Memory of Rebecca McNally Gilden - Blessed mother, wife, daughter, engineer, friend and breast cancer advocate

Reprogramming innate-adaptive immune interactions to eliminate metastatic breast cancer

Abstract Report

Stuart Martin, PhD

University of Maryland School of Medicine

Presented In Memory of Wendy Taylor by Northwest Arkansas Metsquerade

Reducing the risk of chemotherapy-induced scattering of metastatic triple-negative breast tumors

Abstract Report

Danny Welch, PhD

University of Kansas Cancer Center

Presented In Memory of Valerie Wright by Northwest Arkansas Metsquerade

New inhibitors of breast cancer metastasis

Abstract Report

Andrei Bakin, PhD

Roswell Park Cancer Center

A Novel Combination Therapy to Improve Treatment of Metastatic Breast Cancer

Abstract Report

Sanchita Bhatnagar, PhD

University of Virginia School of Medicine

Targeting the mechanisms of oncogenic TRIM37 in metastatic triple negative breast cancer

Abstract Report

Rolf Brekken, PhD

UT Southwestern

Pleiotrophin as a driver of the immune metastatic niche

Abstract Report

Andrew Brenner, MD, PhD

Mays Cancer Center

Presented In Memory of Tarah Harvey by Minneapolis Metsquerade

Permeability of Sacituzumab Govitecan in Breast Cancer Brain Metastases

Abstract Report

Barbara Fingleton, PhD

Vanderbilt University

Presented In Memory of Destiny Rivera and Stephanie Sunday by Orlando Metsquerade

Tumor targeting of an immune super-activator in male and female metastatic breast cancer

Abstract Report

Barry Hudson, PhD

University of Miami

Presented in memory of Amanda De Fiebre by Southwest Florida Metsquerade

Therapeutic targeting of RAGE in metastatic breast cancer

Abstract Report

Yibin Kang, PhD

Princeton University

Presented by The Fraternal Order of Eagles

Preventing Regulatory T cell Induction to Enhance Immunity Against Breast Cancer Metastases

Abstract Report

Stephen Kron, MD, PhD

The University of Chicago

Mechanisms determining local and systemic anti-tumor immune response after metastasis-directed image-guided radiation combined w

Abstract Report

Sandra McAllister, PhD

Brigham and Women's Hospital; Harvard Medical School

Presented In Memory of Lauren Smoke by Chicago Metsquerade

A new approach to identifying effective therapeutic strategies that eliminate de novo and recurrent stage IV triple-negative bre

Abstract Report

Yusuke Shiozawa, MD, PhD

Wake Forest University

An osteolytic bone lesion-targeted radiopharmaceutical for bone metastatic breast cancer

Abstract Report

Zena Werb, PhD

University of California, San Francisco

Presented by METAvivor Facebook Fundraisers

Identification of Novel Cell Targets for Metastatic Breast Cancer Therapy

Abstract Report

Jing Yang, PhD

University of California, San Diego

Overcoming therapy resistance in TNBC metastases through targeted inhibition of Periostin

Abstract Report

Dihua Yu, PhD

The University of Texas

Presented In loving memory of Tiffany Foust and Kriss Fierro by Monica Hill's Be Bold and Behold

Impeding Breast Cancer Brain Metastasis by Blocking CCR2+ Myeloid Cell Infiltration

Abstract Report

2018

JULIO AGUIRRE-GHISO, PhD

Icahn School of Medicine

Targeting Intrinsic And Immune Mechanisms In Persistent Dormant Cancer Cells In Stage IV Breast Cancer

Abstract Report

CHARLES CLEVENGER, MD, PhD

Virginia Commonwealth University

Inhibition of breast cancer metastatic outgrowth with non-immunosuppressive cyclosporine

Abstract Report

VERA DONNENBERG, PhD

University of Pittsburgh School of Medicine UPMC Hillman Cancer Center

Assays to determine optimal dosing and therapeutic effects of localized immunotherapy for established metastatic breast cancer t

Abstract Report

GLORIA ECHEVERRIA, PhD

MD Anderson Cancer Center

Elucidation and functionalization of transcriptomic heterogeneity of established multi-organ metastases in patient-derived xenog

Abstract Report

DORRAYA EL-ASHRY, PhD

University of Minnesota School of Medicine

Eliminate breast cancer metastasis by targeting the tumor microenvironment

Abstract Report

XU FENG, PhD

University of Alabama at Birmingham

Development of Targeted Drugs for Treating Breast Cancer Bone Metastasis

Abstract Report

JANET FUNK, MD

University of Arizona Cancer Center

Improving Survival in Stage IV Breast Cancer by Targeting Dormant Breast Cancer Cells in Bone

Abstract Report

ANA GARRIDO-CASTRO, MD

Dana-Farber Cancer Institute

Identifying predictive biomarkers of response to PD-1 inhibition in metastatic triple-negative breast cancer

Abstract Report

MARK HEADLEY, PhD

Fred Hutchinson Cancer Research Center

Monocyte Contribution To Lung Metastasis Of Breast Cancer

Abstract Report

FRANSISCA LEONARD, PhD

Houston Methodist Hospital Research Institute

CRISPR-nanoparticle for macrophage reprogramming: New therapeutic strategy for breast cancer liver metastasis

Abstract Report

SOPHIA LUNT, PhD

Michigan State University

Targeting Sialic Acid Metabolism to Stop Metastatic Breast Cancer

Abstract Report

ELIZABETH MCDONALD, MD, PhD

University of Pennsylvania

In vivo visualization and quantification of pharmacodynamics response to PARPi therapy

Abstract Report

ERIK NELSON, PhD

University of Illinois

Targeting an immune-suppressive cholesterol metabolite in the treatment metastatic breast cancer

Abstract Report

JOSH NEMAN, PhD

University of Southern California

Chemotherapy and tau interplay permeabilize BBB and facilitate brain metastasis

Abstract Report

AXEL SCHÖNTHAL, PhD

University of Southern California

Controlled Opening of the Blood-Brain Barrier to Achieve Therapeutic Access of Trastuzumab in HER2-Positive Brain Metastases

Abstract Report

BRAD ST CROIX, PhD

National Cancer Institute

Improving Immunotherapies for Advanced Metastatic Breast Cancer

Abstract Report

RACHEL STEWART, PhD

University of Kentucky

Characterizing Metastatic Breast Cancer Heterogeneity through Post-Mortem Tissue Collection

Abstract Report

WEI TAO, PhD

Harvard Medical School/Brigham and Women’s Hospital

Multi-staged delivery system overcoming the physiological barriers for metastatic breast cancer (MBC) therapy

Abstract Report

MICHAEL WENDT, PhD

Purdue University

Enhancing anti-metastatic immunity through targeted inhibition of SHP2 phosphatase

Abstract Report

THOMAS WESTBROOK, PhD

Baylor College of Medicine

Microenvironment response disparities of metastatic TNBC to multi-tyrosine kinase inhibition

Abstract Report

DIHUA YU, MD, PhD

MD Anderson Cancer Center

Combating Breast Cancer Brain Metastasis by Blocking CDK5 Driver Kinase Function

Abstract Report

FIONA YULL, PhD

Vanderbilt School of Medicine

Macrophage-based immunotherapy for eradication of pre-existing breast cancer metastases

Abstract Report

ANDREI GOGA, MD, PhD

University of California, San Francisco

Targeting the MYC Pathway in Metastatic Breast Cancer

Abstract Report

2017

DIANA CITTELLY, PhD

University of Colorado Anschutz Medical Campus

Targeting BDNF/TrkB in Brain Metastasis from Young Women with TNBC

Abstract Report

MICHAEL FLISTER, PhD

Medical College of Wisconsin

Personalized Therapy for Curing Metastatic Breast Cancer

Abstract Report

MELANIE HAYDEN GEPHART, MD, MAS

Leland Stanford Junior University

Halting the Progression of Breast Cancer Leptomeningeal Brain Metastases

Abstract Report

CHERYL JORCYK, PhD

Boise State University

High Impact Therapeutic for the Elimination of Breast Cancer Metastasis to Bone

Abstract Report

JAMES MCINTYRE, MA, PhD AND BARBARA FINGLETON, PhD

Vanderbilt University

A Novel Self-Reporting Paclitaxel Prodrug without Systemic Neurotoxicity: Preclinical Assessment for Targeted Treatment of Metas

Abstract Report

VIVEK MITTAL, PhD

Weill Medical College of Cornell University

Targeting Epigenetic Regulator PRC2 as a Therapy for Established Metastasis

Abstract Report

PARTHA ROY, PhD

University of Pittsburgh

Pharmacological Inhibition of Myocardin-Family Proteins as a Novel Strategy to Combat Metastatic Breast Cancer

Abstract Report

REBECCA WATTERS, PhD

University of Pittsburgh

Discovery of Clinically Actionable Genes in Breast Cancer Bone Metastases

Abstract Report

KATHERINE LOREE COOK, PhD

Wake Forest University

Dietary Considerations Effecting Lung Metastatic Therapeutic Responsiveness and Co-Morbidities

Abstract Report

Summary Report

JOSHUA DONALDSON, MD, PhD

Johns Hopkins University

Resistance Mechanisms to Palbociclib in Hormone Positive Metastatic Breast Cancer

Abstract Report

Summary Report

GINA SIZEMORE, PhD

Ohio State University

Targeting Novel Tumor-Stroma Interactions in Breast Cancer Brain Metastases

Abstract Report

Summary Report

DAVID SOTO-PANTOJA, PhD

Wake Forest School of Medicine Comprehensive Cancer Center

Anti-CD47 Immunotherapy as a Treatment for Metastatic Breast Cancer

Abstract Report

Summary Report

2016

PAULA BOS, PhD

Virginia Commonwealth University

Regulatory T Cell Promotion of Brain Metastatic Processes

Abstract Report

IAN CORBIN, PhD

University of Texas Southwestern Medical Center

Lipoprotein Omega-3 Fatty Acid Nanoparticles: A Novel Treatment for Breast Cancer Liver Metastases

Abstract Report

KATHLEEN GALLO, PhD

Michigan State University

Deciphering and Targeting Signaling Nodes that Drive Metastatic Breast Cancer

Abstract Report

TODD GIORGIO, PhD

Vanderbilt University

Quantitative Characterization of Anti-Tumor Immune Response in Metastatic Breast Cancer Induced by Focused Ultrasound

Abstract Report

PATRICIA SHEEAN, PhD, RDN

Loyola University Chicago

Is lean soft tissue (i.e., skeletal muscle) a potentially modifiable biomarker predictive of prognosis, treatment tolerance and

Abstract Report

KATHRYN SCHWERTFEGER, PhD

University of Minnesota

Development of Immune-based Strategies to Enhance Therapeutic Targeting of Metastatic Breast Cancer

Abstract Report

Summary Report

BRAD ST. CROIX, PhD

National Cancer Institute Center for Cancer Research

Improving Therapy for Metastatic Breast Cancer through Targeting of Tumor Stroma

Abstract Report

Summary Report

2015

SENDURAI A. MANI, PhD

University of Texas MD Anderson Cancer Center

Targeting Cancer Stem Cells to Treat Metastasis

Abstract Report

Summary Report

J. CHUCK HARRELL, PhD

Virginia Commonwealth University

Genomic Dissection of Patient-Derived Xenograft Breast Cancer Liver Metastasis Models

Abstract Report

Summary Report

YIBIN KANG, PhD

Princeton University

Development of a Humanized Mouse Model of Breast Cancer Liver Metastasis

Abstract Report

Summary Report

YIBIN KANG, PhD

Princeton University

Sensitizing Bone Metastasis to Chemotherapy and Radiotherapy by Targeting Jagged1-Mediated Tumor-Stromal Interactions

Abstract Report

Summary Report

BONNIE KING, PhD and CHRISTOPHER CONTAG, PhD

Stanford University

Modeling Therapeutic Strategies for Breast Cancer Metastasis to Bone

Abstract Report

Summary Report

JITESH PRATAP, PhD

Department of Anatomy & Cell Biology

Novel Regulatory Mechanisms of Cell Survival During Bone Metastasis of Breast Cancer

Abstract Report

Summary Report

TIFFANY SEAGROVES, PhD

University of Tennesee Health Science Center

Targeting Creatine Kinases to Inhibit Metastatic Breast Cancer

Abstract Report

Summary Report

GEORGE SGOUROS, PhD

Johns Hopkins University, School of Medicine

A Pre-Clinical Model of anti-HER2/neu-Antibody Reactive Breast Cancer Metastases

Abstract Report

Summary Report

HAIFA SHEN, PhD, MD

Houston Methodist Research Institute

Harnessing Vascular and Cellular Depots of Nanotherapeutics for the Treatment of Metastatic Breast Cancer

Abstract Report

Summary Report

KAY-UWE WAGNER, Phd

University of Nebraska Medical Center

Identification of Candidate Target Genes for Metastasis and Cancer Cell Dormancy in a Novel Triple-Negative Breast Cancer Model

Abstract Report

Summary Report

MICHAEL WENDT, PhD

Purdue University Center for Cancer Research

Targeting Growth-Factor Receptor Discordant Metastatic Breast Cancer

Abstract Report

Summary Report

ELIZABETH YEH, PhD

Medical University of South Carolina

Application of a Connexin 43 (Cx43) Targeted Agent for the Treatment of Metastatic Breast Cancer

Abstract Report

Summary Report